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PLoS One. 2020 Oct 12;15(10):e0239604. doi: 10.1371/journal.pone.0239604. eCollection 2020.
ABSTRACT
Demand for heart transplants far exceeds supply of donated organs. This is attributed to the high percentage of donor hearts that are discarded and to the narrow six-hour time
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Sci Rep. 2020 Oct 16;10(1):17531. doi: 10.1038/s41598-020-73150-9.
ABSTRACT
Xenotransplantation using pig organs has achieved survival times up to 195 days in pig orthotopic heart transplantation into baboons. Here we demonstrate that in addition to an improved immunosuppressive regimen, non-ischaemic
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Clin Transplant. 2020 Dec;34(12):e14122. doi: 10.1111/ctr.14122. Epub 2020 Nov 22.
ABSTRACT
BACKGROUND: Few studies directly compare outcomes between the most commonly used preservation solutions in pediatric heart transplantation in a large cohort of recipients. The purpose of this study
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J Cardiothorac Surg. 2020 Oct 27;15(1):323. doi: 10.1186/s13019-020-01367-w.
ABSTRACT
BACKGROUND: Organ Care System (OCS) minimizes the cold ischemic time and allows for optimization of logistics and meticulous recipient preparation. Impact of normothermic ex-vivo preservation using OCS compared with cold
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J Heart Lung Transplant. 2021 Jan;40(1):69-86. doi: 10.1016/j.healun.2020.10.004. Epub 2020 Oct 14.
ABSTRACT
Despite the advancements in medical treatment, mechanical support, and stem cell therapy, heart transplantation remains the most effective treatment for selected patients with advanced heart failure.
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Transplantation. 2021 Jul 1;105(7):1510-1515. doi: 10.1097/TP.0000000000003531.
ABSTRACT
BACKGROUND: Donation after circulatory death (DCD) represents an increasing source of organs. However, evaluating the suitability of DCD hearts for transplantation represents a challenge. Contractile function is the ultimate determinant of recovery.
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Nat Commun. 2020 Nov 13;11(1):5765. doi: 10.1038/s41467-020-19581-4.
ABSTRACT
Lung transplantation remains the best treatment option for end-stage lung disease; however, is limited by a shortage of donor grafts. Ex situ lung perfusion, also known as ex vivo lung perfusion,
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J Surg Res. 2021 Mar;259:242-252. doi: 10.1016/j.jss.2020.09.040. Epub 2020 Nov 26.
ABSTRACT
BACKGROUND: The optimal substrate for hypothermic machine perfusion preservation of donor hearts is unknown. Fatty acids, acetate, and ketones are preferred substrates of the heart during normothermic
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Am J Transplant. 2021 Apr;21(4):1597-1602. doi: 10.1111/ajt.16446. Epub 2021 Jan 2.
ABSTRACT
Heart transplantation from controlled donation after the circulatory determination of death (cDCDD) may help to increase the availability of hearts for transplantation. During 2020, four heart transplants
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Transplant Proc. 2021 Mar;53(2):612-619. doi: 10.1016/j.transproceed.2020.10.001. Epub 2020 Dec 2.
ABSTRACT
BACKGROUND: Use of donation after circulatory death (DCD) hearts is becoming more prevalent in cardiac transplantation. However, there is no standardized approach to myocardial preservation, and little data
