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[Approval] Hypothermic, oxygenated perfusion (HOPE) provides cardioprotection via succinate oxidation prior to normothermic perfusion in a rat model of donation after circulatory death (DCD)

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Am J Transplant. 2021 Mar;21(3):1003-1011. doi: 10.1111/ajt.16258. Epub 2020 Sep 15.

ABSTRACT

In donation after circulatory death (DCD), cardiac grafts are subjected to warm ischemia in situ, prior to a brief period of cold, static storage (CSS) at procurement,

[Approval] Comparing Donor Heart Assessment Strategies During Ex Situ Heart Perfusion to Better Estimate Posttransplant Cardiac Function

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Transplantation. 2020 Sep;104(9):1890-1898. doi: 10.1097/TP.0000000000003374.

ABSTRACT

BACKGROUND: Ex situ heart perfusion (ESHP) limits ischemic periods and enables continuous monitoring of donated hearts; however, a validated assessment method to predict cardiac performance has yet to be established. We compare biventricular

[Approval] Cold non-ischemic heart preservation with continuous perfusion prevents early graft failure in orthotopic pig-to-baboon xenotransplantation

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Xenotransplantation. 2021 Jan;28(1):e12636. doi: 10.1111/xen.12636. Epub 2020 Aug 25.

ABSTRACT

BACKGROUND: Successful preclinical transplantations of porcine hearts into baboon recipients are required before commencing clinical trials. Despite years of research, over half of the orthotopic cardiac xenografts were lost

[Approval] Non-ischemic Heart Preservation via Hypothermic Cardioplegic Perfusion Induces Immunodepletion of Donor Hearts Resulting in Diminished Graft Infiltration Following Transplantation

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Front Immunol. 2020 Jul 28;11:1621. doi: 10.3389/fimmu.2020.01621. eCollection 2020.

ABSTRACT

Introduction: Many donor organs contain significant leukocyte reservoirs which upon transplantation activate recipient leukocytes to initiate acute rejection. We aimed to assess whether non-ischemic heart preservation via ex vivo

[Approval] Normothermic Ex Situ Liver Perfusion Enhances Mitochondrial Function of DCD Grafts as Evidenced by High-throughput Metabolomics

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Transplantation. 2021 Jul 1;105(7):1530-1538. doi: 10.1097/TP.0000000000003476.

ABSTRACT

BACKGROUND: Normothermic ex situ liver perfusion (NEsLP) reduces reperfusion injury of donation after circulatory death (DCD) grafts and optimizes graft function. The goal of our study was to elucidate how NEsLP impacts

[Approval] Preservation by cold storage vs ex vivo normothermic perfusion of marginal donor hearts: clinical, histopathologic, and ultrastructural features

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J Heart Lung Transplant. 2020 Dec;39(12):1408-1416. doi: 10.1016/j.healun.2020.08.021. Epub 2020 Sep 4.

ABSTRACT

BACKGROUND: The aim of this study was to match clinical outcomes of heart transplantation (HTx) against histopathologic and ultrastructural characteristics of marginal grafts preserved by cold