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Nat Commun. 2020 Nov 13;11(1):5765. doi: 10.1038/s41467-020-19581-4.
ABSTRACT
Lung transplantation remains the best treatment option for end-stage lung disease; however, is limited by a shortage of donor grafts. Ex situ lung perfusion, also known as ex vivo lung perfusion,
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Transplantation. 2021 Jul 1;105(7):1510-1515. doi: 10.1097/TP.0000000000003531.
ABSTRACT
BACKGROUND: Donation after circulatory death (DCD) represents an increasing source of organs. However, evaluating the suitability of DCD hearts for transplantation represents a challenge. Contractile function is the ultimate determinant of recovery.
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J Surg Res. 2021 Mar;259:242-252. doi: 10.1016/j.jss.2020.09.040. Epub 2020 Nov 26.
ABSTRACT
BACKGROUND: The optimal substrate for hypothermic machine perfusion preservation of donor hearts is unknown. Fatty acids, acetate, and ketones are preferred substrates of the heart during normothermic
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Transplant Proc. 2021 Mar;53(2):612-619. doi: 10.1016/j.transproceed.2020.10.001. Epub 2020 Dec 2.
ABSTRACT
BACKGROUND: Use of donation after circulatory death (DCD) hearts is becoming more prevalent in cardiac transplantation. However, there is no standardized approach to myocardial preservation, and little data
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Am J Transplant. 2021 Apr;21(4):1597-1602. doi: 10.1111/ajt.16446. Epub 2021 Jan 2.
ABSTRACT
Heart transplantation from controlled donation after the circulatory determination of death (cDCDD) may help to increase the availability of hearts for transplantation. During 2020, four heart transplants
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J Extra Corpor Technol. 2020 Dec;52(4):303-313. doi: 10.1182/ject-2000034.
ABSTRACT
Ex situ heart perfusion (ESHP) has proven to be an important and valuable step toward better preservation of donor hearts for heart transplantation. Currently, few ESHP systems allow for a
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Artif Organs. 2021 Jul;45(7):682-695. doi: 10.1111/aor.13894. Epub 2021 Mar 9.
ABSTRACT
The ever-widening gap between organ supply and demand has resulted in an organ shortage crisis that affects patients all over the world. For decades, static cold storage (SCS)
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Magn Reson Med. 2021 Jun;85(6):3510-3521. doi: 10.1002/mrm.28639. Epub 2020 Dec 23.
ABSTRACT
PURPOSE: Increasing worldwide demand for cardiac transplantation has spurred new developments to increase the donor pool. Normothermic preservation of heart grafts for transplantation is an emerging strategy
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Ann Thorac Surg. 2021 Jan 7:S0003-4975(21)00017-5. doi: 10.1016/j.athoracsur.2020.12.025. Online ahead of print.
ABSTRACT
BACKGROUND: Pediatric heart transplant (HTx) recipients with congenital heart defects require complex concomitant surgical procedures with the risk of prolonging the allograft’s ischemic time. Ex vivo
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Sci Adv. 2021 Jan 8;7(2):eabe3005. doi: 10.1126/sciadv.abe3005. Print 2021 Jan.
ABSTRACT
Nanowarming of cryopreserved organs perfused with magnetic cryopreservation agents (mCPAs) could increase donor organ utilization by extending preservation time and avoiding damage caused by slow and nonuniform rewarming.
