What are the barriers to wider use of organ perfusion?
Another record year for heart transplants: Steep increases seen in DCD transplants in 2022
in focus
A 68% increase in DCD heart transplants was part of a record-setting 2022
Process Engineer
Job Title: Process Engineer
Summary: The process engineer is responsible for the installation, qualification, operation, supervision of a biomedical device assembly facility clean room. The role includes developing standard operating protocols, training materials, scheduling, and reporting activities for manufacturing within a regulatory controlled environment. This includes operations of the facility, electrical, process equipment , HVAC, high
UNOS CEO Brian Shepard to leave organization after a decade of service
United Network for Organ Sharing (UNOS) today announced that CEO Brian Shepard will depart the organization at the end of September, following the completion of his contract. Shepard’s 10-year tenure as UNOS CEO was marked by groundbreaking progress in the U.S. organ donation and transplantation system.
Maureen McBride, Ph.D., UNOS’ chief operating officer, will assume the
[Approval] Preservation by cold storage vs ex vivo normothermic perfusion of marginal donor hearts: clinical, histopathologic, and ultrastructural features
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J Heart Lung Transplant. 2020 Dec;39(12):1408-1416. doi: 10.1016/j.healun.2020.08.021. Epub 2020 Sep 4.
ABSTRACT
BACKGROUND: The aim of this study was to match clinical outcomes of heart transplantation (HTx) against histopathologic and ultrastructural characteristics of marginal grafts preserved by cold
[Approval] Does pediatric heart transplant survival differ with various cardiac preservation solutions?
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Clin Transplant. 2020 Dec;34(12):e14122. doi: 10.1111/ctr.14122. Epub 2020 Nov 22.
ABSTRACT
BACKGROUND: Few studies directly compare outcomes between the most commonly used preservation solutions in pediatric heart transplantation in a large cohort of recipients. The purpose of this study
[Approval] Impact of porcine cytomegalovirus on long-term orthotopic cardiac xenotransplant survival
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Sci Rep. 2020 Oct 16;10(1):17531. doi: 10.1038/s41598-020-73150-9.
ABSTRACT
Xenotransplantation using pig organs has achieved survival times up to 195 days in pig orthotopic heart transplantation into baboons. Here we demonstrate that in addition to an improved immunosuppressive regimen, non-ischaemic
[Approval] Heart transplantation of patients with ventricular assist devices: impact of normothermic ex-vivo preservation using organ care system compared with cold storage
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J Cardiothorac Surg. 2020 Oct 27;15(1):323. doi: 10.1186/s13019-020-01367-w.
ABSTRACT
BACKGROUND: Organ Care System (OCS) minimizes the cold ischemic time and allows for optimization of logistics and meticulous recipient preparation. Impact of normothermic ex-vivo preservation using OCS compared with cold
[Approval] Ex situ heart perfusion: The past, the present, and the future
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J Heart Lung Transplant. 2021 Jan;40(1):69-86. doi: 10.1016/j.healun.2020.10.004. Epub 2020 Oct 14.
ABSTRACT
Despite the advancements in medical treatment, mechanical support, and stem cell therapy, heart transplantation remains the most effective treatment for selected patients with advanced heart failure.
[Approval] Clinical transplantation using negative pressure ventilation ex situ lung perfusion with extended criteria donor lungs
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Nat Commun. 2020 Nov 13;11(1):5765. doi: 10.1038/s41467-020-19581-4.
ABSTRACT
Lung transplantation remains the best treatment option for end-stage lung disease; however, is limited by a shortage of donor grafts. Ex situ lung perfusion, also known as ex vivo lung perfusion,